Objective To explore the effect of the Information-Knowledge-Attitude-Practice (IKAP) nursing model combined with psychological intervention on the nursing outcomes of artificial insemination (AI) patients. Methods 200 patients who underwent artificial insemination at Pingdingshan Maternal and Child Health Care Hospital from January 2021 to January 2024 were randomly divided into a control group (traditional nursing) and an intervention group (IKAP nursing model combined with psychological intervention), with 100 patients in each group. The changes in psychological status [Self-rating Anxiety Scale (SAS) scores, Self-rating Depression Scale (SDS) scores], shame, marital adjustment, nursing satisfaction and pregnancy outcomes [Human chorionic gonadotropin (HCG) positive rate and miscarriage rate] were compared between two groups of patients. Results After intervention, the intervention group showed a significant decrease in SAS and SDS scores compared to the control group (P<0.001), and the improvement in shame and marital adjustment scores was significantly better than that of the control group (P<0.001). The HCG positive rate in the intervention group was 72.0%, significantly higher than the control group’s 58.0% (P=0.033). The miscarriage rate was 8.3%, significantly lower than the control group’s 19.0% (P=0.044). The nursing satisfaction score of the intervention group was (95.4±3.2) points, significantly higher than the control group’s (87.8±4.1) points (P<0.001). Conclusion The IKAP nursing model combined with psychological intervention significantly improves the psychological state, shame, and marital adjustment level of artificial insemination patients, increases nursing satisfaction and pregnancy success rate, reduces the risk of miscarriage, and has high clinical promotion value.